The Week 10 NFL schedule for the 2024 season is loaded with great matchups and we have you covered with what you need to know heading into the weekend. Our NFL Nation reporters bring us the biggest keys to every game and analytics writer Seth Walder makes a bold prediction for each matchup. The ESPN Research team provides a big stat to know and a betting nugget for each contest, while our Football Power Index (FPI) goes inside the numbers with a game projection. Fantasy analyst Eric Moody finds fantasy football X factors, and three analysts — Kalyn Kahler, Moody, and Walder — give us final score picks for every game. Everything you want to know is here in one spot to help you get ready for a loaded NFL weekend.
Let’s get into the full Week 10 slate, including the Giants and Panthers showdown in Munich, Germany, and 49ers running back Christian McCaffrey’s season debut against the Buccaneers. It all culminates with a “Monday Night Football” matchup between the Dolphins and the Rams on ESPN.
Giants (2-7) at Panthers (2-7):
The Giants are favorites for the first time in a while, and the Panthers are underdogs once again. Quarterback Bryce Young will start for the Panthers, who are looking to stop the Giants’ rushing attack. The bold prediction is that there will be zero touchdowns scored in this matchup.
Patriots (2-7) at Bears (4-4):
Quarterback Drake Maye faces off against his friend Caleb Williams in this matchup. The Bears will try to exploit the Patriots’ weak pass block win rate, while the Patriots hope to continue their recent success. The betting nugget is that the Patriots have covered back-to-back games.
Bills (7-2) at Colts (4-5):
Josh Allen leads the Bills against the Colts, who have struggled to contain the run. The bold prediction is that Amari Cooper will catch a 40-plus-yard pass in this game. The Bills are favored in this matchup.
Broncos (5-4) at Chiefs (8-0):
The Broncos take on the Chiefs in a battle of aggressive defenses. The Broncos will try to contain Patrick Mahomes, while the Chiefs look to figure out the Broncos’ defense. The Chiefs are favored in this matchup.
Falcons (6-3) at Saints (2-7):
The Falcons face the Saints, who are under new interim coach Darren Rizzi. The Saints have lost their past seven games, sparking major changes. The Saints are underdogs in this matchup.
Stay tuned for more matchups in Week 10!
