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The NFL Week 2 schedule for the 2024 season is packed with exciting matchups, and we’ve got you covered with everything you need to know heading into the weekend. Our NFL Nation reporters bring you the biggest keys to every game, while analytics writer Seth Walder makes bold predictions for each matchup. The ESPN Research team provides key stats to know and betting insights for each contest, and our Football Power Index (FPI) breaks down the numbers with game projections. Fantasy analyst Eric Moody highlights X factors for fantasy football, and three analysts — Kalyn Kahler, Moody, and Walder — give their final score picks for every game. Get ready for a loaded weekend of NFL football with all the information you need right here.

### Buccaneers Seek Revenge Against Lions
The Buccaneers are on a quest for revenge against the Lions in Week 2. After losing to the Lions twice last year, including a 31-23 defeat in the divisional round of the playoffs, the Buccaneers have had this game circled on their schedule since it was released. However, they will have to rely heavily on their offense as their defense is dealing with injuries. With key defensive players sidelined, the Buccaneers will look to lean on their high-powered offense to secure a win against the Lions. Look for a high-scoring showdown between these two teams.

### QB Showdown Between Burrow and Mahomes
One of the marquee matchups of Week 2 features a classic quarterback showdown between Joe Burrow and Patrick Mahomes. Burrow, coming off a strong performance in Week 1, will look to continue his success against a tough Chiefs defense. Meanwhile, Mahomes, known for his dynamic playmaking ability, will lead the Chiefs in a battle against the Bengals. Expect a high-octane matchup between these two talented quarterbacks as they go head-to-head on the field.

### Monday Night Football: Falcons vs. Eagles
The Monday Night Football matchup between the Falcons and Eagles promises to be an exciting game under the lights. Falcons QB Kirk Cousins will look to build on his success against the Eagles from last season, while the Eagles’ defense will aim to contain Cousins and the Falcons’ offense. Keep an eye on the edge rushers for the Eagles, as they will play a crucial role in pressuring Cousins and disrupting the Falcons’ passing game. With both teams eager for a win, expect a competitive and entertaining game on Monday night.

In Week 2, there are several intriguing matchups to watch, including the Buccaneers seeking revenge against the Lions, a classic QB showdown between Joe Burrow and Patrick Mahomes, and a Monday Night Football clash between the Falcons and Eagles. With key storylines and bold predictions for each game, along with fantasy tips and betting insights, we have you covered for a thrilling weekend of NFL football. Get ready for an action-packed slate of games as the 2024 season continues to unfold.